Source: Assessing the Binding Properties of the anti-PD-1 Antibody Landscape (2020)

Summary

Peer-reviewed industry collaboration (Brown et al., 2020, PLOS ONE) measuring anti-PD-1 monoclonal antibody binding kinetics and epitope diversity using label-free biosensors, including the Carterra LSA platform compared to a Biacore 8K.

Useful Claims

• Brown, M.E., et al., "Assessing the binding properties of the anti-PD-1 antibody landscape using label-free biosensors," PLOS ONE, vol. 15, no. 3, e0229206, 2020. DOI 10.1371/journal.pone.0229206.
• The abstract states PD-1/mAb binding kinetics were measured by surface plasmon resonance using a Carterra LSA instrument, with results compared to a Biacore 8K.
• On flat chip types, the abstract reports LSA and 8K platforms yielded near-identical kinetic rate and affinity constants relative to solution-phase methods.
• The LSA was also used for epitope binning that revealed over ten unique competitive binding profiles among the tested anti-PD-1 mAbs.

Reliability Notes

Primary tier by venue. The paper validates the LSA as an instrument used in collaborative pharmaceutical antibody-characterization research; it does not establish Carterra's market share, revenue, or Utah employment.

Related Pages

• Carterra