# Source: Assessing the Binding Properties of the anti-PD-1 Antibody Landscape (2020)

**Type:** source
**Status:** Useful
**Confidence:** Medium
**Source Type:** peer-reviewed
**URL:** https://doi.org/10.1371/journal.pone.0229206
**Publisher:** PLOS ONE
**Retrieved:** 2026-08-12
**Updated:** 2026-08-11

## Summary

Peer-reviewed industry collaboration (Brown et al., 2020, *PLOS ONE*) measuring anti-PD-1 monoclonal antibody binding kinetics and epitope diversity using label-free biosensors, including the Carterra LSA platform compared to a Biacore 8K.

## Useful Claims

- Brown, M.E., et al., "Assessing the binding properties of the anti-PD-1 antibody landscape using label-free biosensors," *PLOS ONE*, vol. 15, no. 3, e0229206, 2020. DOI **10.1371/journal.pone.0229206**.
- The abstract states PD-1/mAb binding kinetics were measured by surface plasmon resonance using a **Carterra LSA instrument**, with results compared to a Biacore 8K.
- On flat chip types, the abstract reports LSA and 8K platforms yielded near-identical kinetic rate and affinity constants relative to solution-phase methods.
- The LSA was also used for epitope binning that revealed over ten unique competitive binding profiles among the tested anti-PD-1 mAbs.

## Reliability Notes

Primary tier by venue. The paper validates the LSA as an instrument used in collaborative pharmaceutical antibody-characterization research; it does not establish Carterra's market share, revenue, or Utah employment.

## Related Pages

- [Carterra](carterra.md)