# Official Website: Spire Therapeutics

**Type:** source
**Status:** Useful
**Confidence:** Medium
**Source Type:** Official Website
**URL:** https://spire.us/
**Publisher:** SPIRE (Spire Therapeutics)
**Accessed:** 2026-06-19
**Updated:** 2026-06-19

## Summary

SPIRE's official website describes Diadem, a low-intensity focused ultrasound (LIFU) device for surgery-free, drug-free treatment of chronic pain and depression by noninvasively modulating hyperactive deep brain circuits, with patient-specific compensation for skull and hair acoustic distortions.

## Useful Claims

- SPIRE positions Diadem as an ultrasonic device that noninvasively and precisely resets deep brain circuits hyperactive in chronic pain and depression.
- The site states Diadem compensates for ultrasound distortions caused by the head and hair to deliver controlled, practical therapy.
- SPIRE cites approximately 20 million people in the United States with treatment-resistant chronic pain and 6 million with treatment-resistant depression.
- The site claims clinical studies have shown rapid, immediate improvements in pain intensity and depressive symptoms.
- SPIRE lists funders and partners including the National Institutes of Health, National Science Foundation, Focused Ultrasound Foundation, University of Utah Health, Wellcome Trust, and private investors.
- The site reports pitch-competition wins at Altitude Lab DEMO day (October 3, 2024) and the Wilson Sonsini Entrepreneur & Investor Life Science Summit (August 27, 2024).
- SPIRE invites patients with chronic pain or depression who have not benefited from existing treatments to sign up for respective clinical studies.

## Reliability Notes

This is an official company source. Epidemiology figures, clinical-outcome claims, and mechanism-of-action statements on a company site are leads, not independent verification. Trial enrollment status, regulatory pathway, and comparative efficacy versus TMS, ECT, or DBS should be confirmed against clinical-trial registries, peer-reviewed publications, and FDA device databases before high-confidence use.

## Related Pages

- [Spire Therapeutics](spire-therapeutic.md)